Armageddon arrived on a weekday, which was really inconvenient for a lot of people, including The Four Horsemen of the Apocalypse. After their appearance on The Kayla Mangrabler talk show, they decided to go their separate ways and cause as much havoc as possible. Jesus has been stuck at the craps table for three days, sipping vodka and Red Bull, completely missing the end of the world. But he is about to meet up with Death and go on a road trip that will test their resolve and blood alcohol content. Meanwhile, an unlikely band of heroes are headed to Las Vegas to fight the Apocalypse. Creepy Chuzz and his one-armed, addict monkey Phil are flying there in an ice cream truck. Chuzz's best friend Leon plans to lend a hand, assuming he can escape the clutches of the insane Father Maniwhore not to mention Pestilence, who has designs on the janitor's bathtub-LSD-addled brain. Along the way they will encounter bouncing glory hole boxes, militant lesbians, an undead general, a flying demon named Princess Sally, hordes of zombies, and a trio of secret agents hell-bent on delivering a Cease and Desist order to Lucifer himself. They'd better hurry, because the Devil is rising in the desert, and he is hungry to start the Apocalypse that his son, the Anti-Christ could not. But only if he can get it on with his giant floating glory hole.